A custom-built setup for chronic electrophysiological and video recording includes a specialized cage equipped with low-noise amplifiers (LNA) and simultaneous recording capabilities for EEG, Vagus Nerve activity and video. This setup ensures high-fidelity recordings of both neural and behavioral data, providing a detailed and accurate representation of the animal’s physiological and neurological states. The LNAs minimize interference, enhancing the accuracy of the electrical signals captured from the brain and peripheral nerves. The ability to record EEG and VENG alongside video enables the study of brain-vagus nerve interactions and the correlation of neural data with observable behaviors. This comprehensive system is essential for advancing our understanding of the complex autonomic and neurological dynamics in epilepsy and other neurological disorders.